Santiago Correa (email | web): is currently a NCI F32 Postdoctoral Fellow in the Materials Science and Engineering Department at Stanford University, where he works on immunomodulatory biomaterials in the Appel Lab. Santiago is primarily interesting in developing nanotechnology for both macro- and nanoscale drug delivery vehicles, and particularly on their unique ability to engage and communicate with the body's immune system. His postdoctoral research in the Appel Lab is focused on developing injectable hydrogels that stimulate the immune system to recognize and eliminate cancer. Santiago is especially interested in leveraging the controlled drug delivery capabilities provided by nanomaterials to explore combination immunotherapy and the relationship between release kinetics and therapeutic efficacy and safety. Prior to his postdoctoral work, Santiago received his PhD in Biological Engineering from MIT, where he engineered nanoparticle surface chemistries to target ovarian cancer and to fabricate multifunctional nanomaterials in Paula Hammond's Research Group. Specifically, Santiago explored nanoparticle surfaces through supramolecular and covalent modifications to simultaneously control functions such as cellular affinity, subcellular trafficking, gene delivery, and theranostic capabilities. Before his graduate training, Santiago obtained his BS in Biomedical Engineering from Yale University, where he conducted research on the foreign body response to brain implants in the Kyriakides Lab.
Talk details: Precisely coordinating the power of the immune system through supramolecular soft biomaterials
Biomaterials that precisely manipulate the immune system can unlock unprecedented advances for complex diseases including cancer, infectious disease, and autoimmune disorders. In this talk, I describe how self-assembled, nanoparticle-based hydrogel technologies improve our ability to locally engage the immune system for safer, more effective cancer immunotherapy.