Lexy von Diezmann (email | twitter: @lexy_von_diez) received her BA in Chemistry from Reed College in 2011 and PhD in Chemical Physics from Stanford University in 2018. Her graduate work focused on the development of multicolor 3D single-molecule microscopy methods, and on their application to tracking molecular trajectories within an asymmetrically dividing bacterium. Her current work in soft matter as a postdoc at the University of Utah builds on these earlier observations of how protein scaffolds act to coordinate signaling, extending these insights to chromosome dynamics and DNA repair in C. elegans. In addition to research, Lexy is committed to building an inclusive community in STEM, acting as a co-organizer of the LGBTQ+STEM Interest Group at Utah and as a mentor for graduate students.
Talk details: A liquid crystal compartmentalizes meiotic DNA repair signals
During sexual reproduction, a tightly-regulated number of DNA breaks are repaired to form physical linkages, or crossovers, between parental chromosomes. The synaptonemal complex (SC) is a proteinaceous liquid crystal that spans the interface between parental chromosomes and regulates crossovers along their lengths. In my talk, I will describe how single-molecule tracking of pro-crossover signals within the SC scaffold supports a diffusive mechanism for how crossover distributions are regulated.